PRP & PRF Therapy in CalgaryPlatelet-Rich Plasma & FibrinHair & Skin Rejuvenation

At our Calgary clinic, PRP (platelet-rich plasma) and PRF (platelet-rich fibrin) therapies use your own blood's concentrated growth factors to support repair and rejuvenation. A small sample of your blood is drawn and spun in a centrifuge to concentrate the platelet-rich portion, which is then carefully injected or microneedled into the treatment area. These growth factors signal your skin and hair follicles to regenerate.

In 2026, we added PRF to our offerings as we continue to actively research the best treatments, procedures, and protocols for our clients and patients. PRF is now our preferred and primary regenerative treatment, because we believe it offers important advantages over PRP for many skin and hair goals. This is not a replacement of PRP: we still offer PRP so you can make an informed choice based on your goals, your budget, and what our team recommends for you.

Both PRP and PRF come from your own blood, so they are well tolerated with little risk of allergic reaction. The difference is in how they are prepared and how they release growth factors. PRP releases its growth factors quickly. PRF is prepared without anticoagulants, forms a natural fibrin scaffold, and releases growth factors slowly over 7 to 14 days. For skin, these treatments improve texture, tone, fine lines, and overall glow. For hair, they support healthier follicles, improve the appearance of thickness, and help reduce shedding in appropriate candidates.

Why We Recommend PRF

PRP and PRF are both established regenerative options, and both are used successfully for skin and hair treatments. We recommend PRF for most clients because of how it is made and how it behaves once injected. Many PRP protocols add an anticoagulant, use a double spin, and remove much of the white blood cell fraction, releasing growth factors more quickly after activation. PRF is drawn with nothing added and prepared in a single spin, forming a three-dimensional fibrin scaffold that retains platelets, white blood cells, and growth factors and releases them gradually over one to two weeks. PRP is activated and releases most of its growth factors almost immediately, while PRF holds them within the scaffold and releases them as it naturally breaks down over 7 to 14 days. That slower, sustained release keeps the regenerative signal active for longer, which is why PRF results build gradually and last longer.

A growing body of research supports PRF. Studies have reported that fluid PRF outperformed PRP for atrophic acne scars (Archives of Dermatological Research, 2022), that injectable PRF produced statistically significant gains in under-eye skin density and thickness (Journal of Cosmetic Dermatology, 2025), and that repeated i-PRF sessions delivered measurable facial rejuvenation (PubMed, 2020). For hair, one study reported an 80% response rate after six monthly i-PRF sessions for androgenetic alopecia (PubMed, 2025), while PRP retains a deeper evidence base, including a meta-analysis of nine randomized trials (PubMed, 2023). The evidence does not yet show one modality to be universally superior to the other, and larger randomized trials are still needed; we track this research as it evolves and update our protocols accordingly.

PRP or PRF: Which Is Right for You?

PRF is our default recommendation for skin rejuvenation, under-eye quality, acne scars, and hair restoration, because of its slow release and additive-free fibrin scaffold. PRP remains a great option and is sometimes preferred, for example when a faster release is desired. At your consultation we assess your skin or hair, review your history, and recommend PRF or PRP based on what will give you the best outcome. You always make the final choice.

Both treatments work well on their own or combined with other services. They pair exceptionally well with microneedling for collagen induction, and many patients also combine them with chemical peels, Botox, or dermal fillers to support recovery and results.

Our C-PRF Protocol

For our injectable PRF treatments we follow the C-PRF (Concentrated PRF) protocol, in which the spin deliberately concentrates platelets and white blood cells into a small cell-rich layer just above the buffy coat. In a C-PRF harvesting study, Miron and colleagues reported a roughly 10-fold increase in platelets and leukocytes compared with whole blood, considerably higher than standard injectable PRF. For context, typical PRP concentrates platelets roughly 5-fold over whole blood, and standard injectable PRF about 2- to 3-fold. C-PRF reaches roughly 10-fold, about twice the concentration of typical PRP and roughly 3 to 5 times that of standard injectable PRF. Actual concentration varies by centrifuge, tube type, processing time, and patient factors.

In practical terms, C-PRF gives us a more concentrated, cell-rich injectable while keeping everything that makes PRF appealing: no anticoagulants, no additives, a natural fibrin scaffold, and a slow, sustained release of your own growth factors.